abstract：:Ca2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca2+ storage inside the cell, but mitochondria have long been recognized as a fundamental Ca2+ pool. Protozoan parasite...

journal_title：International journal of molecular sciences

authors： Scarpelli PH,Pecenin MF,Garcia CRS

更新日期：2021-01-05 00:00:00

abstract：:Plants encounter a variety of mechanical stimuli during their growth and development. It is currently believed that mechanosensitive ion channels play an essential role in the initial perception of mechanical force in plants. Over the past decade, the study of Piezo, a mechanosensitive ion channel in animals, has made...

journal_title：International journal of molecular sciences

authors： Fang X,Liu B,Shao Q,Huang X,Li J,Luan S,He K

更新日期：2021-01-05 00:00:00

abstract：:Salivary gland dysfunction induces salivary flow reduction and a dry mouth, and commonly involves oral dysfunction, tooth structure deterioration, and infection through reduced salivation. This study aimed to investigate the impact of aging on the salivary gland by a metabolomics approach in an extensive aging mouse m...

journal_title：International journal of molecular sciences

authors： Toan NK,Tai NC,Kim SA,Ahn SG

更新日期：2021-01-02 00:00:00

abstract：:Many heritable genetic disorders arise from nonsense mutations, which generate premature termination codons (PTCs) in transcribed mRNA. PTCs ablate protein synthesis by prematurely terminating the translation of mutant mRNA, as well as reducing mutant mRNA quantity through targeted degradation by nonsense-mediated dec...

journal_title：International journal of molecular sciences

authors： McHugh DR,Cotton CU,Hodges CA

更新日期：2020-12-31 00:00:00

abstract：:Cadmium (Cd) is an anthropogenic as well as a naturally occurring toxicant associated with prediabetes and T2DM in humans and experimental models of Cd exposure. However, relatively few studies have examined the mechanism(s) of Cd-induced hyperglycemia. The purpose of this study was to examine the role of pancreatic i...

journal_title：International journal of molecular sciences

authors： Fitzgerald R,Olsen A,Nguyen J,Wong W,El Muayed M,Edwards J

更新日期：2020-12-31 00:00:00

abstract：:The demise of retinal ganglion cells (RGCs) is characteristic of diseases of the retina such as glaucoma and diabetic or ischemic retinopathies. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that mediates neuroprotection and inhibition of angiogenesis in the retina. We have studied exp...

journal_title：International journal of molecular sciences

authors： Bürger S,Meng J,Zwanzig A,Beck M,Pankonin M,Wiedemann P,Eichler W,Unterlauft JD

更新日期：2020-12-31 00:00:00

abstract：:While drug resistant mutations in HIV-1 are largely credited to its error prone HIV-1 RT, the time point in the infection cycle that these mutations can arise and if they appear spontaneously without selection pressures both remained enigmatic. Many HIV-1 RT mutational in vitro studies utilized reporter genes (LacZ) a...

journal_title：International journal of molecular sciences

authors： Yeo JY,Koh DW,Yap P,Goh GR,Gan SK

更新日期：2020-12-31 00:00:00

abstract：:Galectins are a family of animal lectins with high affinity for β-galactosides. Galectins are able to bind to bacteria, and a few mammalian galectins are known to kill the bound bacteria. In fish, no galectins with direct bactericidal effect have been reported. In the present study, we identified and characterized a t...

journal_title：International journal of molecular sciences

authors： Zhang T,Jiang S,Sun L

更新日期：2020-12-31 00:00:00

abstract：:This Special Issue of International Journal of Molecular Sciences (IJMS) contains 7 reviews and 12 original research papers written by a panel of experts who highlight recent advances in molecular structure and cellular function of purinergic P2 receptors[...]. ...

journal_title：International journal of molecular sciences

authors： Zemkova H

更新日期：2020-12-31 00:00:00

abstract：:In this study, drug nanocarriers were designed using linear copolymers with different contents of cholinium-based ionic liquid units, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium chloride (TMAMA/Cl: 25, 50, and 75 mol%). The amphiphilicity of the copolymers was evaluated on the basis of their critical micelle con...

journal_title：International journal of molecular sciences

authors： Niesyto K,Neugebauer D

更新日期：2020-12-30 00:00:00

abstract：:Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM's ability to adapt to binding targets with different structures is related to the flexible centra...

journal_title：International journal of molecular sciences

authors： Andrews C,Xu Y,Kirberger M,Yang JJ

更新日期：2020-12-30 00:00:00

abstract：:Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflamma...

journal_title：International journal of molecular sciences

authors： Ravaut G,Légiot A,Bergeron KF,Mounier C

更新日期：2020-12-30 00:00:00

abstract：:The core of micelles self-assembled from amphiphiles is hydrophobic and contains little water, whereas complex coacervate core micelles co-assembled from oppositely charged hydrophilic polymers have a hydrophilic core with a high water content. Co-assembly of ionic surfactants with ionic-neutral copolymers yields surf...

journal_title：International journal of molecular sciences

authors： Timmers EM,Magana JR,Schoenmakers SMC,Fransen PM,Janssen HM,Voets IK

更新日期：2020-12-30 00:00:00

abstract：:The phylum Thermotogae is composed of a single class (Thermotogae), 4 orders (Thermotogales, Kosmotogales, Petrotogales, Mesoaciditogales), 5 families (Thermatogaceae, Fervidobacteriaceae, Kosmotogaceae, Petrotogaceae, Mesoaciditogaceae), and 13 genera. They have been isolated from extremely hot environments whose cha...

journal_title：International journal of molecular sciences

authors： Lanzilli M,Esercizio N,Vastano M,Xu Z,Nuzzo G,Gallo C,Manzo E,Fontana A,d'Ippolito G

更新日期：2020-12-30 00:00:00

abstract：:ATP is a major energy source in the mammalian cells, but it is an extracellular chemical messenger acting on P2 purinergic receptors. A line of evidence has shown that ATP is released from many different types of cells including neurons, endothelial cells, and muscle cells. In this review, we described the distributio...

journal_title：International journal of molecular sciences

authors： Woo SH,Trinh TN

更新日期：2020-12-29 00:00:00

abstract：:Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or impaired mental and/or intellectual functioning. Contracting ske...

journal_title：International journal of molecular sciences

authors： Sui SX,Williams LJ,Holloway-Kew KL,Hyde NK,Pasco JA

更新日期：2020-12-29 00:00:00

abstract：:Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulation...

journal_title：International journal of molecular sciences

authors： Curci C,Picerno A,Chaoul N,Stasi A,De Palma G,Franzin R,Pontrelli P,Castellano G,Pertosa GB,Macchia L,Di Lorenzo VF,Sabbà C,Gallone A,Gesualdo L,Sallustio F

更新日期：2020-12-29 00:00:00

abstract：:Fabry disease (FD) is a lysosomal storage disorder caused by mutations of the GLA gene that lead to a deficiency of the enzymatic activity of α-galactosidase A. Available therapies for FD include enzyme replacement therapy (ERT) (agalsidase alfa and agalsidase beta) and the chaperone migalastat. Despite the large body...

journal_title：International journal of molecular sciences

authors： Azevedo O,Gago MF,Miltenberger-Miltenyi G,Sousa N,Cunha D

更新日期：2020-12-28 00:00:00

abstract：:Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Skeletal dysplasia and the related clinical features of MPS IVA are caused by disruption of the cartilage and its extracellular matrix, leading to a growth imbalance. Enzym...

journal_title：International journal of molecular sciences

authors： Álvarez VJ,Bravo SB,Chantada-Vazquez MP,Colón C,De Castro MJ,Morales M,Vitoria I,Tomatsu S,Otero-Espinar FJ,Couce ML

更新日期：2020-12-28 00:00:00

abstract：:The tumor microenvironment (TME) has become the focus of interest in cancer research and treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are secreted by cancer and neighboring cells. The ECM serves both to anchor the tumor cells embedded in it and as a means of communication betwee...

journal_title：International journal of molecular sciences

authors： Niland S,Eble JA

更新日期：2020-12-28 00:00:00

abstract：:Prenatal smoke exposure (PreSE) is a risk factor for nicotine dependence, which is further enhanced by postnatal smoke exposure (PostSE). One susceptibility gene to nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine in the liver. Higher CYP2A6 activity is...

journal_title：International journal of molecular sciences

authors： Lkhagvadorj K,Zeng Z,Meyer KF,Verweij LP,Kooistra W,Reinders-Luinge M,Dijkhuizen HW,de Graaf IAM,Plösch T,Hylkema MN

更新日期：2020-12-26 00:00:00

abstract：:Juglone, a major naphthalenedione component of walnut trees, has long been used in traditional medicine as an antimicrobial and antitumor agent. Nonetheless, its impact on oocyte and preimplantation embryo development has not been entirely clarified. Using the bovine model, we sought to elucidate the impact of juglone...

journal_title：International journal of molecular sciences

authors： Mesalam AA,El-Sheikh M,Joo MD,Khalil AAK,Mesalam A,Ahn MJ,Kong IK

更新日期：2020-12-26 00:00:00

abstract：:Metformin has demonstrated substantial potential for use in cancer treatments. Liver kinase B (LKB)-AMP-activated protein kinase (AMPK) and mTOR are reported to be the main targets of metformin in relation to its ability to prevent cancer cell proliferation. However, the role of metformin in the control of neoplastic ...

journal_title：International journal of molecular sciences

authors： Qu Z,Ji S,Zheng S

更新日期：2020-12-26 00:00:00

abstract：:Calcium (Ca2+) plays an important role in regulating the differentiation and function of osteoclasts. Calcium oscillations (Ca oscillations) are well-known phenomena in receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis and bone resorption via calcineurin. Many modifiers are involve...

journal_title：International journal of molecular sciences

authors： Okada H,Okabe K,Tanaka S

更新日期：2020-12-26 00:00:00

abstract：:Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its selectively high expression on tumor vessels and its correlation with poor survival in cancer patients led to the exploration of endoglin as a ...

journal_title：International journal of molecular sciences

authors： Liu Y,Paauwe M,Nixon AB,Hawinkels LJAC

更新日期：2020-12-25 00:00:00

abstract：:Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular mice...

journal_title：International journal of molecular sciences

authors： Ilhami FB,Peng KC,Chang YS,Alemayehu YA,Tsai HC,Lai JY,Chiao YH,Kao CY,Cheng CC

更新日期：2020-12-25 00:00:00

abstract：:Breast cancer is the main cause of morbidity and mortality in women worldwide. However, the molecular pathogenesis of breast cancer remains poorly defined due to its heterogeneity. Several studies have reported that G Protein-Coupled Estrogen Receptor 1 (GPER1) plays a crucial role in breast cancer progression, by bin...

journal_title：International journal of molecular sciences

authors： Vivacqua A

更新日期：2020-12-24 00:00:00

abstract：:Stearoyl-CoA desaturase 1 (SCD1), an enzyme that is involved in the biosynthesis of monounsaturated fatty acids, induces the reprogramming of cardiomyocyte metabolism. Thyroid hormones (THs) activate both lipolysis and lipogenesis. Many genes that are involved in lipid metabolism, including Scd1, are regulated by THs....

journal_title：International journal of molecular sciences

authors： Olichwier A,Balatskyi VV,Wolosiewicz M,Ntambi JM,Dobrzyn P

更新日期：2020-12-24 00:00:00

abstract：:Red fluorescent genetically encoded calcium indicators (GECIs) have expanded the available pallet of colors used for the visualization of neuronal calcium activity in vivo. However, their calcium-binding domain is restricted by calmodulin from metazoans. In this study, we developed red GECI, called FRCaMP, using calmo...

journal_title：International journal of molecular sciences

authors： Subach OM,Barykina NV,Chefanova ES,Vlaskina AV,Sotskov VP,Ivashkina OI,Anokhin KV,Subach FV

更新日期：2020-12-24 00:00:00

abstract：:The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in t...

journal_title：International journal of molecular sciences

authors： Bonfiglio R,Granaglia A,Giocondo R,Scimeca M,Bonanno E

更新日期：2020-12-24 00:00:00

abstract：:Cell death represents a basic biological paradigm that governs outcomes and long-term sequelae in almost every hepatic disease. Necroptosis is a common form of programmed cell death in the liver. Necroptosis can be activated by ligands of death receptors, which then interact with receptor-interactive protein kinases 1...

journal_title：International journal of molecular sciences

authors： Xue C,Gu X,Li G,Bao Z,Li L

更新日期：2020-12-23 00:00:00

abstract：:The packaging of the eukaryotic genome into chromatin regulates the storage of genetic information, including the access of the cell's DNA metabolism machinery. Indeed, since the processes of DNA replication, translation, and repair require access to the underlying DNA, several mechanisms, both active and passive, hav...

journal_title：International journal of molecular sciences

authors： Morgan A,LeGresley S,Fischer C

更新日期：2020-12-23 00:00:00

abstract：:MET-amplified gastric cancer cells are extremely sensitive to MET inhibition in vitro, whereas clinical efficacy of MET inhibitors is disappointing. The compensatory activation of other oncogenic growth factor receptors may serve as an underlying mechanism of resistance. In this study, we analyzed the role of HER rece...

journal_title：International journal of molecular sciences

authors： Jenke R,Holzhäuser-Rein M,Mueller-Wilke S,Lordick F,Aigner A,Büch T

更新日期：2020-12-23 00:00:00

abstract：:GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golg...

journal_title：International journal of molecular sciences

authors： Sanwald JL,Dobner J,Simons IM,Poschmann G,Stühler K,Üffing A,Hoffmann S,Willbold D

更新日期：2020-12-23 00:00:00

abstract：:Our laboratory and others have previously shown that cannabinoid receptor type-1 (CB1r) activity is neuroprotective and a modulator of brain ageing; a genetic disruption of CB1r signaling accelerates brain ageing, whereas the pharmacological stimulation of CB1r activity had the opposite effect. In this study, we have ...

journal_title：International journal of molecular sciences

authors： Gargano A,Beins E,Zimmer A,Bilkei-Gorzo A

更新日期：2020-12-22 00:00:00

abstract：:To increase the efficiency of therapy via enhancing its selectivity, the usage of gold nanorods (GNR) as a factor sensitizing cancer cells to radiation was proposed. Due to gold nanoparticles' characteristics, the smaller doses of radiation would be sufficient in the treatment, protecting the healthy tissue around the...

journal_title：International journal of molecular sciences

authors： Musielak M,Boś-Liedke A,Piotrowski I,Kozak M,Suchorska W

更新日期：2020-12-22 00:00:00

abstract：:Central hypogonadism is a clinical condition, characterized by sexual symptoms and low serum testosterone levels, due to an impaired function of the hypothalamus or pituitary gland. Testosterone replacement therapy (TRT) is the standard treatment for hypogonadism, but it has some disadvantages. TRT is not a good optio...

journal_title：International journal of molecular sciences

authors： Ide V,Vanderschueren D,Antonio L

更新日期：2020-12-22 00:00:00

abstract：:Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...

journal_title：International journal of molecular sciences

authors： Karnaneedi S,Huerlimann R,Johnston EB,Nugraha R,Ruethers T,Taki AC,Kamath SD,Wade NM,Jerry DR,Lopata AL

更新日期：2020-12-22 00:00:00

abstract：:Zika virus (ZIKV) acquired a special relevance due to the pandemic that occurred in the Americas in 2015, when an important number of fetal microcephaly cases occurred. Since then, numerous studies have tried to elucidate the pathogenic mechanisms and the potential therapeutic approaches to combat the virus. Cellular ...

journal_title：International journal of molecular sciences

authors： Gasco S,Muñoz-Fernández MÁ

更新日期：2020-12-22 00:00:00

abstract：:Sarcopenia has a significant negative impact on healthspan in the elderly and effective pharmacologic interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump. We asked whether restoring SERCA activity using...

journal_title：International journal of molecular sciences

authors： Qaisar R,Pharaoh G,Bhaskaran S,Xu H,Ranjit R,Bian J,Ahn B,Georgescu C,Wren JD,Van Remmen H

更新日期：2020-12-22 00:00:00